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Of these, 16 compounds were successfully identified, while three remained unknown (LRI: 1110, 1195, and 1302)

doi: 10.1186/s12984-024-01422-w 10 CabinioM.RossettoF.IserniaS.SaibeneF

developed a bio-activated self-assembling peptide (BIVA-PK) that induces FN1 + SPP1 + Mrc1 + macrophage death and functional alteration, remodeling the renal immune microenvironment to block AKI-CKD transition, highlighting the therapeutic promise of targeting macrophages in CKD [335]

Combining GST inhibitors with other therapeutic agents targeting different cellular pathways may further enhance efficacy and reduce dependence on a single target

This is mainly due to high costs and ethical standards of animal studies and the benefits of in vitro models providing a microenvironment that advances studies of cellular processes on a molecular level [9,10]

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